Early Skeletal Muscle Adaptations to Short-Term High-Fat Diet in Humans Prior to Changes in Insulin Sensitivity
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چکیده
of baseline measurements, a 7-day control diet, pre HFD measurements, a 5-day HFD period, and post HFD measurements. Studies 1 and 2 differed in that study 1 included an IVGTT on day 8 and 14, whereas study 2 included a high fat meal challenge on day 8 and 14. Intravenous glucose tolerance test (IVGTT). All volunteers were fasted and placed in the supine position prior to the IVGTT, before high SFA feeding, and after high SFA
منابع مشابه
Early skeletal muscle adaptations to short-term high-fat diet in humans before changes in insulin sensitivity.
OBJECTIVE The purpose of this investigation was to understand the metabolic adaptations to a short-term (5 days), isocaloric, high-fat diet (HFD) in healthy, young males. METHODS Two studies were undertaken with 12 subjects. Study 1 investigated the effect of the HFD on skeletal muscle substrate metabolism and insulin sensitivity. Study 2 assessed the metabolic and transcriptional responses i...
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